A rare cause of intestinal polyposis

A rare cause of intestinal polyposis

A 53-year-old patient of Vietnamese descent presented us with persistent diarrhea and weight loss of 7 kg in front. In addition to mild abdominal pain, alopecia had progressed for four months and onychodystrophy of the fingers and toes for one month. Endoscopy showed intestinal polyposis (> 100 polyps) without evidence of malignancy or inflammatory bowel disease. A polypectomy was performed diagnostically with evidence of hamartomatous polyps. Looking at the findings together, the presence of Cronkhite-Canada syndrome was diagnosed. This non-hereditary syndrome, which is rare with an assumed incidence of 1: 1,000,000, manifests itself in intestinal polyposis, alopecia, onychodystrophy and hyperpigmentation. Immunosuppression takes place therapeutically. Colorectal cancer appears to be more common, so annual colonoscopies are recommended. On medication with prednisolone, the alopecia and onychodystrophy improved with progressive polyposis and persistent diarrhea. Satisfactory symptom control was achieved after escalation to infliximab. The patient subsequently refused any further immunosuppressive therapy and underwent colectomy in Vietnam.

Dr. med. Victor J. Keim, ViDia Kliniken Karlsruhe, victor.keim@vincentius-ka.de

Prof. Dr. med. Liebwin Goßner, Medical Clinic II, Städtisches Klinikum Karlsruhe

Conflict of interest: The authors declare that there is no conflict of interest.

Citation : Keim VJ, Goßner L: A rare cause of intestinal polyposis. Dtsch Arztebl Int 2019; 116: 388. DOI: 10.3238 / arztebl.2019.0388

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