Kiel - Medicine is faced with the challenge of continuing to guarantee the successful treatment of bacterial infections - despite the ever-smaller spectrum of effective antibiotics. The latest research results from Kiel scientists could now show ways in which the antibiotics that are still available remain effective for longer.
The team around Hinrich Schulenburg and Gunther Jansen from the Evolutionary Ecology and Genetics working group examined how the alternating administration of two in antibiotic pairs commonly used in clinical practice affects the bacterium Pseudomonas aeruginosa. This is often multi-resistant and can cause life-threatening infections in immunocompromised patients or chronic diseases.
For the examinations Evolution experiments carried out in the laboratory under controlled conditions. The quick change between two antibiotics, so-called antibiotic cycling, proved to be highly effective against the germ. At the same time, it inhibited the bacterium's development of resistance to the drugs. The research group published its results in the journal Evolutionary Applications (doi 10.1111 / eva.12330).
Antibiotic cycling is already common in everyday treatment, but so far the various preparations have been given for several weeks at time. According to the working group, these intervals are probably too long. The researchers used clinically relevant antibiotics every twelve hours and compared this regimen with the long-term administration of single antibiotic.
"We were surprised that in our experiments, despite the non-lethal dosage of the antibiotics, we managed to eliminate Bacterial populations could reach. A temporally complex environment, as it is created by the rapid change of the various antibiotics, seems to overwhelm the resistance mechanisms of Pseudomonas aeruginosa in these cases, "says Schulenburg.
" The development of new drugs is not moving with the speed can keep up with which the evolution of pathogens creates new resistance to treatment. Our approach therefore aims to use the existing active ingredients more sensibly, ”says Roderich Römhild, first author of the study.